Europe PMC

High activity of the endogenous opioid system and acute but not chronic stress influence experimental colitis development in mice.

Author information

Affiliations

  • 1. Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland.
      Authors
    • Zielinska M 1
    • Szymaszkiewicz A 1
    • Salaga M 1
    • Zatorski H 1
    • Wlodarczyk J 1
    • Fichna J 1
    (6 authors)
  • 2. Department of Cytobiochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland.
      Authors
    • Jacenik D 2
    • Krajewska WM 2
    (2 authors)
  • 3. Department of Pathology, Faculty of Medicine, Medical University of Lodz, Lodz, Poland.
      Authors
    • Kordek R 3
    (1 author)
  • 4. Department of Neuropeptides, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.
      Authors
    • Misicka A 4
    (1 author)
  • 5. Laboratory of Neurogenomics, Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec/Magdalenka, Poland.
      Authors
    • Sacharczuk M 5
    (1 author)

ORCIDs linked to this article

Show all (9)

Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society, 01 Oct 2018, 69(5)
https://doi.org/10.26402/jpp.2018.5.11 PMID: 30683828 

Abstract 

Exposition to environmental factors is one of the major underlying causes in inflammatory bowel diseases (IBD), with several endogenous systems involved. Our aim was to characterize the impact of stress on the colitis development in relation to the endogenous opioid system (EOS) activity in mice. A unique mouse model of high and low activity of EOS (namely high (HA)/low (LA) stress-induced analgesia) was employed. Mice were bred using bidirectional selection and classified as HA or LA line based on the measurement of analgesia. Colitis was induced by instillation of trinitrobenzenesulfonic acid in 30% EtOH/0.9% NaCl. After 4 days, the macroscopic score was assessed and samples for molecular and histological studies were collected. To evaluate the influence of stress on colitis development, chronic mild stress (exposure to stress stimuli for 2 and 5 weeks) and acute stress (short restraint over 3 days) were applied before colitis induction. We observed a difference in the colitis development between non-stressed HA and LA mice, as indicated by macroscopic and ulcer scores. Acute stress improved colitis in HA mice but did not change the inflammation score in LA line as compared to respective non-stressed mice. Chronic mild stress had no influence on colitis in either of mouse lines. Our study supports the hypothesis that the activity of EOS may be crucial in IBD development. We also evidence that acute, but not chronic stress influenced IBD exacerbation, depending on EOS function.

Full text links 

Read article at publisher's site: https://doi.org/10.26402/jpp.2018.5.11

Citations & impact 

Impact metrics

2
Citations
Jump to Citations

Article citations

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.

    • Annotations
      In abstract (21)
    • Get citation
    • Claim to ORCID