We also observed a reverse dose-dependent shift in the relative expression of chitinase 1: the group with DSS-induced colitis treated with OAT-177 at the dose of 100 mg/kg (p.o.)showed the highest chitinase 1 mRNA level (16.35 ± 2.28), while the expression in the group treated with the dose of 30 mg/kg (p.o.)was similar to the control animals (0.64 ± 0.94 vs. 0.13 ± 0.08, respectively) (Figure 3B). Here, CHIT1 is linked to colitis.