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Shenling Baizhu Powder Alleviates TNBS-Induced Colitis in Rats by Improving Intestinal Epithelial Permeability and Inhibiting Inflammation Through the TLR5/MyD88/NF-κB Pathway.

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Affiliations

  • 1. Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China.
      Authors
    • Rao K 1
    • Zhan K 1
    (2 authors)
  • 2. The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
      Authors
    • Qin S 2
    • Wu H 2
    • Zheng H 2
    • Huang S 2, 3
    (4 authors)
  • 3. Dongguan Hospital of Guangzhou University of Chinese Medicine, Dongguan, China.
      Authors
    • Yang Y 3
    • Huang S 2, 3
    (2 authors)

ORCIDs linked to this article

Frontiers in Pharmacology, 28 Apr 2022, 13:883918
https://doi.org/10.3389/fphar.2022.883918 PMID: 35571126 PMCID: PMC9096158

This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
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Abstract 

Aim of the study: To evaluate the protective effect and mechanism of shenling baizhu powder (SBP) on TNBS-induced colitis. Methods: Rats were given TNBS to establish the model of colitis and subsequently treated with different doses of SBP or mesalamine (MES). In addition, the expression of the TLR5/MyD88/NF-κB signaling pathway and critical targets of the intestinal mucosal barrier was detected by immunochemical analysis techniques. Results: SBP significantly ameliorated the symptoms of TNBS-induced colitis in rats and reduced the secretion of pro-inflammatory cytokines. SBP could effectively strengthen epithelial barrier integrity in TNBS-induced colitis by increasing the secretion of mucin and tight junction and inhibiting apoptosis. Furthermore, we identified the crucial role of the TLR5/MyD88/NF-κB signaling pathway in exerting the therapeutic effect of SBP. Conclusion: The results of our study suggest that SBP has therapeutic effects on TNBS-induced colitis and potential value in treating and maintaining remission of colitis.

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    Funding 

    Funders who supported this work.

    National Natural Science Foundation of China (1)

    • Grant ID: 82174318

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    Special Project for Research and Development in Key areas of Guangdong Province (1)

    • Grant ID: SZ2021ZZ13 SZ2021ZZ25 SZ2021ZZ44 SZ2021ZZ02

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