Europe PMC

Adipose-derived stem cells show hepatic differentiation potential and therapeutic effect in rats with acute liver failure.

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Affiliations

  • 1. Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
      Authors
    • Jin Y 1
    • Qi T 1
    • Li Q 1
    • Xu J 1
    • Fu Q 1
    • Zhang X 1
    (6 authors)
  • 2. Department of Interventional & Vascular Surgery, Affiliated Hospital of Nantong University, Nantong 226001, China.
      Authors
    • Shi R 2
    • Chen C 2
    (2 authors)
  • 3. East Hospital, School of Medicine, Tongji University, Shanghai 200120, China.
      Authors
    • Gao S 3
    • Yang D 3
    • Xu J 3
    (3 authors)
  • 4. Shanghai Eighth People's Hospital Affiliated to Jiangsu University, Shanghai 200233, China.
      Authors
    • Gao F 4
    (1 author)
  • 5. Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China.
      Authors
    • Sun G 5
    (1 author)

Acta Biochimica et Biophysica Sinica, 01 Apr 2023, 55(4):601-612
https://doi.org/10.3724/abbs.2023072 PMID: 37078751 PMCID: PMC10195146

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Abstract 

Hepatocyte transplantation contributes to the repair of liver damage, but hepatocyte resources are limited, making it difficult for this to become a routine treatment. Previous studies have confirmed that mesenchymal stem cells (MSCs) can be induced to differentiate into hepatocyte-like cells (HLCs) by adding different cytokine combinations in vitro, and they then play some roles of hepatocytes. Our previous studies found that the differentiation ability of stem cells is closely related to the origin of the tissue. To identify the mesenchymal stem cells that are most suitable for hepatic differentiation and the treatment of liver failure, we use a three-phase induction process in which human adipose-derived stem cells (hADSCs) and umbilical cord mesenchymal stem cells (hUCMSCs) are induced to differentiate towards HLCs in vitro, and rats with acute liver failure (ALF) induced by D-gal are cured by MSCs and MSC-derived HLCs (MSCs-HLC), respectively. We find that hADSCs are stronger than hUCMSCs in hepatic differentiation ability, and they have a better curative effect when using hADSCs-HLC or jointly using hADSCs and hADSCs-HLC, which has positive significance for hepatocyte regeneration, recovery of liver function and reduction of systemic inflammatory reaction, finally improving the survival rate of rats with acute liver failure.

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