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Autophagy is essential for human myelopoiesis.

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Affiliations

  • 1. CAS Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Centre for Regenerative Medicine and Health, Hong Kong Institute of Science and Innovation, Hong Kong, Chinese Academy of Sciences, Guangzhou 510530, China; University of Chinese Academy of Sciences, Beijing 100049, China; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Center for Cell Lineage and Development, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
      Authors
    • Gu J 1
    • Huang Y 1
    • Zhang Y 1
    • Xing Q 1
    • Li F 1
    • Hu X 1
    (6 authors)
  • 2. CAS Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Centre for Regenerative Medicine and Health, Hong Kong Institute of Science and Innovation, Hong Kong, Chinese Academy of Sciences, Guangzhou 510530, China; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Center for Cell Lineage and Development, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
      Authors
    • Zhu Y 2
    • Lin H 2
    • Kang B 2
    • Zhang Z 2
    • Wang M 2
    • Zhou T 2
    • Mai Y 2
    • Chen Q 2
    • Peng J 2
    • Wang J 2
    • Gao M 2
    • Shan Y 2
    (12 authors)
  • 3. Department of Hematology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.
      Authors
    • Wang S 3
    • Long B 3
    (2 authors)
  • 4. Shandong Medicinal Biotechnology Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250012, China.
      Authors
    • Guo X 4
    • Cui Y 4
    (2 authors)
  • 5. CAS Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Centre for Regenerative Medicine and Health, Hong Kong Institute of Science and Innovation, Hong Kong, Chinese Academy of Sciences, Guangzhou 510530, China; University of Chinese Academy of Sciences, Beijing 100049, China; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Center for Cell Lineage and Development, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; Shandong Medicinal Biotechnology Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250012, China.
      Authors
    • Pan G 5
    (1 author)

Stem Cell Reports, 11 Jan 2024, 19(2):196-210
https://doi.org/10.1016/j.stemcr.2023.12.005 PMID: 38215759 PMCID: PMC10874853

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Abstract 

Emergency myelopoiesis (EM) is essential in immune defense against pathogens for rapid replenishing of mature myeloid cells. During the EM process, a rapid cell-cycle switch from the quiescent hematopoietic stem cells (HSCs) to highly proliferative myeloid progenitors (MPs) is critical. How the rapid proliferation of MPs during EM is regulated remains poorly understood. Here, we reveal that ATG7, a critical autophagy factor, is essential for the rapid proliferation of MPs during human myelopoiesis. Peripheral blood (PB)-mobilized hematopoietic stem/progenitor cells (HSPCs) with ATG7 knockdown or HSPCs derived from ATG7-/- human embryonic stem cells (hESCs) exhibit severe defect in proliferation during fate transition from HSPCs to MPs. Mechanistically, we show that ATG7 deficiency reduces p53 localization in lysosome for a potential autophagy-mediated degradation. Together, we reveal a previously unrecognized role of autophagy to regulate p53 for a rapid proliferation of MPs in human myelopoiesis.

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Read article at publisher's site: https://doi.org/10.1016/j.stemcr.2023.12.005

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    Funding 

    Funders who supported this work.

    Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences

      Innovation and Technology Commission

        National Key Research and Development Program of China Stem Cell and Translational Research (1)

        National Natural Science Foundation of China (3)

        Natural Science Foundation of Guangdong Province (1)

        • Grant ID: 2020A1515010139

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        Youth Innovation Promotion Association of the Chinese Academy of Sciences

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