Europe PMC

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Reversal of liver failure using a bioartificial liver device implanted with clinical-grade human-induced hepatocytes.

Author information

Affiliations

  • 1. Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China; Zhejiang Minimal Invasive Diagnosis and Treatment Technology Research Center of Severe Hepatobiliary Disease, Hangzhou 310016, China; Key Laboratory of Laparoscopic Technology of Zhejiang Province, Hangzhou 310016, China.
      Authors
    • Wang Y 1
    • Cai X 1
    (2 authors)
  • 2. Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.
      Authors
    • Zheng Q 2
    • Zhang X 2
    • Jin Y 2
    • Yan T 2
    • Wang Z 2
    • Gu Q 2
    • Lv X 2
    • Nan J 2
    • Wu Z 2
    (9 authors)
  • 3. School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
      Authors
    • Sun Z 3
    (1 author)
  • 4. State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Science, Shanghai 200031, China.
      Authors
    • Wang C 4
    • Cen J 4
    • Wu B 4
    • Zhang L 4
    (4 authors)
  • 5. School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.
      Authors
    • Sun W 5
    (1 author)
    • Show all (7)

ORCIDs linked to this article

Cell Stem Cell, 13 Apr 2023, 30(5):617-631.e8
https://doi.org/10.1016/j.stem.2023.03.013 PMID: 37059100 

Abstract 

Liver resection is the first-line treatment for primary liver cancers, providing the potential for a cure. However, concerns about post-hepatectomy liver failure (PHLF), a leading cause of death following extended liver resection, have restricted the population of eligible patients. Here, we engineered a clinical-grade bioartificial liver (BAL) device employing human-induced hepatocytes (hiHeps) manufactured under GMP conditions. In a porcine PHLF model, the hiHep-BAL treatment showed a remarkable survival benefit. On top of the supportive function, hiHep-BAL treatment restored functions, specifically ammonia detoxification, of the remnant liver and facilitated liver regeneration. Notably, an investigator-initiated study in seven patients with extended liver resection demonstrated that hiHep-BAL treatment was well tolerated and associated with improved liver function and liver regeneration, meeting the primary outcome of safety and feasibility. These encouraging results warrant further testing of hiHep-BAL for PHLF, the success of which would broaden the population of patients eligible for liver resection.

Full text links 

Read article at publisher's site: https://doi.org/10.1016/j.stem.2023.03.013

References 

Citations & impact 

Impact metrics

25
Citations
Jump to Citations
1
Data citation
Jump to Data

Citations of article over time

loading

Article citations

loading

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.

    Funding 

    Funders who supported this work.

    Chinese Academy of Sciences (1)

    • Grant ID: XDA16020201

      Loading publications

    Ministry of Science and Technology of the People's Republic of China

      National Key Research and Development Program of China (2)

      • Grant ID: 2020YFC2002803

        Loading publications

      • Grant ID: 2020YFA0112503

        Loading publications

      National Natural Science Foundation of China (2)

      • Grant ID: 32221002

        Loading publications

      • Grant ID: 32070797

        Loading publications

      Science and Technology Commission of Shanghai Municipality (1)

      • Grant ID: 22JC1403001

        Loading publications

      Shanghai Jiao Tong University

        Shanxi Provincial Key Research and Development Project (2)

        • Grant ID: 2020C03122

          Loading publications

        • Grant ID: 2018C03083

          Loading publications

        University of Minnesota

          Youth Innovation Promotion Association of the Chinese Academy of Sciences

            • Save
            • Claim to ORCID