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Decreased expression of Calpain-9 predicts unfavorable prognosis in patients with gastric cancer.

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Affiliations

  • 1. Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
      Authors
    • Peng P 1
    • Wu W 1
    • Song S 1
    • Jia D 1
    • Shao M 1
    • Zhang M 1
    • Li L 1
    • Wang L 1
    • Yang C 1
    • Wu H 1
    • Ruan Y 1
    • Gu J 1, 3
    (12 authors)
  • 2. Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
      Authors
    • Zhao J 2
    • Wang X 2
    • Shen Z 2
    (3 authors)
  • 3. Institute of Biomedical Science, Fudan University, Shanghai 200032, China.
      Authors
    • Duan F 3
    • Zhao R 3
    • Zhang J 3
    • Gu J 1, 3
    (4 authors)

Scientific Reports, 12 Jul 2016, 6:29604
https://doi.org/10.1038/srep29604 PMID: 27404891 PMCID: PMC4941732

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Abstract 

Calpain-8 and calpain-9 belong to the family of calcium-dependent cysteine proteases, which are highly expressed in the stomach. However, the roles of calpain-8 and calpain-9 in gastric tumorigenesis remain little understood. Herein, we demonstrated that calpain-9 was generally decreased in gastric cancer cell lines and primary tumor tissues, while calpain-8 expression was not significantly altered. Calpain-9, but not calpain-8, induced cell cycle arrest in the G1 phase and cellular apoptosis in vitro, and it attenuated the growth of subcutaneous tumor xenografts in vivo. Low expression of calpain-9 was positively associated with male sex, late T stage, lymph node metastasis, and advanced TNM stage. Further analysis identified calpain-9 as an independent prognostic factor for poor prognosis, and combining calpain-9 with TNM stage generated a better predictive model for patient outcomes. In conclusion, calpain-9 is a tumor suppressor that can be regarded as a potential prognosis indicator for clinical outcomes in gastric cancer.

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