Europe PMC

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

The role of growth hormone in modulation of the immune response.

K W Kelley
Department of Animal Sciences, University of Illinois, Urbana 61801.

Author information

Affiliations

  • 1 author
    1. Department of Animal Sciences, University of Illinois, Urbana 61801.

Annals of the New York Academy of Sciences, 01 Jan 1990, 594:95-103
DOI: 10.1111/j.1749-6632.1990.tb40471.x PMID: 2198842 

Review

Abstract 

Growth hormone was originally discovered because of its ability to promote linear growth in rodents and humans. It is now known that this molecule also augments a number of activities of leukocytes, such as antibody synthesis, cytolytic activity of T lymphocytes, natural killer cell activity, differentiation of neutrophils, production of tumor necrosis factor-alpha (TNF-alpha), and the synthesis of a thymic hormone known as thymulin. We have shown that growth hormone mimics one action of interferon-gamma (IFN-gamma) by augmenting the production of superoxide anion by macrophages and neutrophils. Growth hormone also is synthesized by leukocytes, which creates the possibility that it may act locally as a cytokine in lymphoid tissue. These findings show that a hormone that was originally isolated from the pituitary gland is involved in regulating host defense responses of leukocytes.

Full text links 

Read article at publisher's site (DOI): 10.1111/j.1749-6632.1990.tb40471.x

References 

Articles referenced by this article (31)

Show 10 more references (10 of 31)

Citations & impact 

Impact metrics

46
Citations
Jump to Citations

Citations of article over time

Alternative metrics

Altmetric item for https://www.altmetric.com/details/16669684
Altmetric
Discover the attention surrounding your research
https://www.altmetric.com/details/16669684

Smart citations by scite.ai
Smart citations by scite.ai include citation statements extracted from the full text of the citing article. The number of the statements may be higher than the number of citations provided by EuropePMC if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles.
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1111/j.1749-6632.1990.tb40471.x

Supporting
Mentioning
Contrasting
1
44
0

Article citations

Go to all (46) article citations

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.

Funding 

Funders who supported this work.

NIA NIH HHS (1)

Claim to ORCIDGet citation