Immunohistochemical images, qRT-PCR, and TCGA data analysis confirm the downregulation of E-cadherin (  CDH1 ) in  BRAF mut organoids as well as in  BRAF mut CRC, suggesting that the decrease in cell–cell adhesion in  BRAF mut CRC facilitates invasive and metastatic migration. This evidence concerns the gene BRAF and colorectal carcinoma.