Five of 6 TdT+ leukaemias showed high levels of GC receptors and a favourable response to VP therapy, whereas 1 acute lymphoblastic leukaemia (ALL) and 3 of chronic myelogenous leukaemia (CML) cases in blast crisis with no TdT activity showed low level of GC receptors and poor response to VP therapy. This evidence concerns the gene DNTT and leukemia.