In contrast, among elderly women, HOMA-β values in the obese group were comparable to those in the non-obese group regardless of early and late elderly.<h4>Conclusions</h4>In elderly men, insulin resistance associated with obesity was firmly present regardless of age, whereas, in elderly women, there is no difference in basal insulin secretion between the obese and non-obese groups irrespective of age. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.