The expression of gene and protein biomarkers related to neuronal survival like mammalian target of rapamycin (mTOR), mitogen-activated extracellular signal-regulated kinase 1/2 (MEK1/2), rapid accelerated fibrosarcoma-1 (Raf-1), serine/threonine kinase 1 (AKT1), vascular endothelial growth factor (VEGF), and VEGF receptor 2 (VEGFR2) in EAPO- treated rMc-1 were compared with control group under different glucose concentrations.<h4>Results</h4>Phytochemical analysis of EAPO revealed the presence of diterpenoids, monoterpene esters, phenolic glycosides, and saturated fatty acids. This evidence concerns the gene VEGFA and fibrosarcoma.