TLR7 and multiple sclerosis: Interestingly, an endogenous ligand of TLR7, U11snRNA, was detected in the sera of 2D2Tg<i>Dcir</i> <sup>-/-</sup> mice and the patients of multiple sclerosis, indicating excessive DC activation by TLR7-mediated signaling in 2D2Tg<i>Dcir</i> <sup>-/-</sup> mice and patients with a neuronal autoimmune disease.