The area under the curve (AUC) of SF-AGR was 0.9504, which was superior to SE-AGR (AUC = 0.8682), ESR (AUC = 0.8427), CRP (AUC = 0.8507), and SF-PMN% (AUC = 0.8843), indicating that SF-AGR showed the most outstanding performance in the preoperative diagnosis of PJI.<h4>Conclusion</h4>SF-AGR shows promise as a novel biomarker for the diagnosis of PJI, supporting its potential use as an adjunct to current diagnostic approaches. The gene discussed is CRP; the disease is juvenile polyposis syndrome.