MARK2 and epilepsy: We present a case of <i>MARK2</i>-related epilepsy and review previously reported cases in the literature.<h4>Case report and review</h4>An 11-year-old male patient with ASD carrying a heterozygous pathogenic variant (c.888 + 1G > A) in <i>MARK2</i> gene experienced his first nocturnal tonic seizure at 5 years 11 months.