In mdx-derived primary skeletal muscle cells, miR-30c-5p restoration was also accompanied by reduced TNF-α and increased IL-10 levels, and rescue experiments supported that these anti-inflammatory effects were at least partly SOCS3-dependent.<h4>Conclusion</h4>These findings suggest that the miR-30c-5p/SOCS3 axis is associated with inflammation- and metabolism-related alterations in DMD and warrants further investigation. Here, TNF is linked to Duchenne muscular dystrophy.