Elevated counts of activated CD4 regulatory T cells (OR = 1.0005, 95% CI = 1.0002-1.0008, p = 0.0013), CD16 on CD14<sup>-</sup> CD16<sup>+</sup> monocytes (OR = 1.0003, 95% CI = 1.0001-1.0006, p = 0.0021), and CD16 on CD14<sup>+</sup> CD16<sup>+</sup> monocytes (OR = 1.0004, 95% CI = 1.0001-1.0008, p = 0.0087) were identified as risk factors for the development of ICC. The gene discussed is CD14; the disease is intrahepatic cholangiocarcinoma.