Additionally, the hippocampal asymmetry and prominent perivascular spaces warrant further investigation into their relevance in KCNQ3-related disorders.<h4>Conclusion</h4>This study expands the clinical and neuroimaging spectrum of KCNQ3-related epileptic encephalopathy, reinforcing its association with neurodevelopmental comorbidities. This evidence concerns the gene KCNQ3 and Epileptic encephalopathy.