The most influential predictors reflected limb perfusion and infection severity and included perfusion grade, ankle-brachial index, maintenance dialysis, white blood cell count, C-reactive protein, and prior minor amputation.<h4>Conclusions</h4>An explainable admission-data model can support early inpatient risk stratification for major amputation in diabetic foot ulcer patients and may help prioritize timely multidisciplinary care. The gene discussed is CRP; the disease is diabetic foot.