Our findings illustrated that ZnO NPs (Z1) alleviated hyperglycemia, cleared amyloid-β accumulation, maintained neural integrity, lessened fat deposition in the liver, and altered the expression of <i>irs2</i>, <i>pi3k</i>, <i>ager</i>, and <i>app</i> genes. The gene discussed is IRS2; the disease is Hyperglycemia.