In addition, mediation analysis showed that both alanine aminotransferase (ALT) and the AST (aspartate aminotransferase)/ALT ratio partially mediated the association of FF-LL with T2DM in postmenopausal women, accounting for 22.0% and 24.9% of the total effect, respectively (both P = 0.040). The gene discussed is GPT; the disease is type 2 diabetes mellitus.