Splicing factor 3B subunit 4 (SF3B4), the core component of the U2 spliceosome, has been implicated in tumorigenesis; however, its post-transcriptional functions and role in metabolic regulation in HCC remain unclear.<h4>Methods</h4>SF3B4 expression and its prognostic significance were assessed using TCGA pan-cancer datasets and clinical HCC samples. Here, SF3B4 is linked to cancer.