Transgenic expression of <i>Hdac7</i> in myeloid cells mimicked the hepatic inflammatory phenotype that was observed in mice fed a high fat, high cholesterol and high sucrose (HFHCHS) diet, an obesity model that mimics some features of metabolic dysfunction-associated steatotic liver disease. The gene discussed is HDAC7; the disease is obesity due to melanocortin 4 receptor deficiency.