Compared to periodontally healthy subjects, lactoferrin levels were significantly higher in individuals with periodontal disease: Ratio of Means (ROM) = 1.77 (95% CI: 1.44-2.24) in unstimulated saliva, ROM = 2.14 (95% CI: 1.38-3.32) in stimulated saliva, and ROM = 8.63 (95% CI: 2.68-27.87) in gingival crevicular fluid. This evidence concerns the gene LTF and periodontal disorder.