Consistently, qPCR and ELISA assays confirmed significant upregulation of <i>CD34</i> and <i>PPARG</i> and downregulation of <i>PTEN</i> in hemorrhagic AML relative to non-hemorrhagic AML (p<0.001).<h4>Conclusions</h4>The developed nomogram serves as a reliable pre-operative tool for individualized risk stratification of AML rupture. Here, PTEN is linked to acute myeloid leukemia.