muciniphila</i> OMVs could mitigate chronic stress-induced CRC progression by regulating the pro-tumorigenic protein Fetuin-A.<h4>Methods and results</h4><i>In vitro</i>, the <i>β</i>-adrenergic agonist isoproterenol (ISO), used to simulate chronic stress, significantly promoted CRC cell proliferation, migration, and invasion while inhibiting cellular uptake of OMVs. The gene discussed is AHSG; the disease is colorectal carcinoma.