RELN and Alzheimer disease: Both TRF and ADF significantly increased reelin concentration and neuronal firing rate (<i>p</i> < 0.01), whereas only TRF led to a significant decrease in <i>α</i>-synuclein levels.<h4>Discussion</h4>These findings suggest that TRF may enhance spatial memory and reduce <i>α</i>-synuclein accumulation in AD rats, possibly through mechanisms associated with synaptic plasticity and neuroprotection.