IFNA1 and systemic lupus erythematosus: However, SLE and CLE pathogenesis is clouded by unknowns including limited understanding of the pathophysiological loss of IFN pathway negative feedback, the complexity of IFN production by non-pDC cells (including pDC plasticity and role of different subsets/states), the role of other cytokines and chemokines in disease pathogenesis, and differences in pDC activation and downstream effects in SLE and CLE.