Endotype analysis based on nasal mucosal immune markers may facilitate precision medicine.<h4>Objective</h4>To compare inflammatory profiles and identify endotypes in AR and NAR through local immune marker detection and correlation analysis.<h4>Methods</h4>This retrospective study enrolled chronic rhinitis patients (January 2023-June 2025) divided into three groups: AR group [ARG, n=40, positive skin prick test and/or serum specific IgE (sIgE)], NAR group (NARG, n=40, negative allergy tests), and control group (CG, n=20). The gene discussed is IGHE; the disease is rhinitis.