In this study, we analyzed a distinct myeloid subset excluded from standard LDG/monocyte gating due to high CD14 and CD15 co-expression.<h4>Methods</h4>Myeloid cell populations were quantified by flow cytometry in freshly isolated blood mononuclear cells (PBMC) from SLE patients (n=143), non-disease controls (n=42) and non-autoimmune atherosclerotic individuals (n=22). This evidence concerns the gene CD14 and systemic lupus erythematosus.