A minor CD16<sup>dim_</sup>nAPC-like subset (CD10<sup>neg</sup>CD66b<sup>high</sup>CD15<sup>low</sup>), suggestive of an immature status, was expanded in SLE and correlated with serum IL-6 and BLyS (p<0.05).<h4>Conclusions</h4>Our findings reveal a previously unrecognized LDG subset with neutrophil and APC-like features that may contribute to immune dysregulation and subclinical carotid arteriopathy in SLE and non-autoimmune individuals. The gene discussed is IL6; the disease is systemic lupus erythematosus.