Docking and molecular dynamics analyses provided preliminary structural plausibility for QL-X-138 as a candidate modulator of the GPX7-associated program.<h4>Conclusion</h4>GPX7 marks a genetically supported fibroblast-associated stromal-innate immune crosstalk state in ulcerative colitis and supports further mechanistic investigation of stromal remodeling and innate inflammatory signaling. The gene discussed is GPX7; the disease is ulcerative colitis.