A four-protein panel (CCL3, CX3CL1, FGF-21, CXCL1) achieved an area under the curve (AUC) of 0.903 for distinguishing Dys-NC from NG-NC, while another panel (TNFB, IL10, IL-12B, CX3CL1) demonstrated an AUC of 0.799 for identifying Dys-VCI among Dys-NC.<h4>Discussion</h4>Our study identified unique inflammatory protein profiles associated with different metabolic and cognitive states, providing insights into inflammatory mechanisms linking dysglycemia and VCI, and highlighting potential biomarker candidates for longitudinal validation. Here, IL12B is linked to nevus comedonicus syndrome.