IDH3A and brain neoplasm: <h4>Background</h4>Regulatory T cells (Tregs) contribute significantly to immune suppression and therapy resistance in isocitrate dehydrogenase (IDH)-wild-type glioblastoma (GBM), a highly aggressive brain tumor with poor prognosis.<h4>Methods</h4>In this study, we developed an artificial intelligence (AI)-powered pathomics model to predict Treg infiltration and stratify prognosis in GBM patients undergoing radiotherapy.