No correlation was found between the serum levels of CD73 and sex, age, tumor size, lymph node metastasis, and other organ metastasis.<h4>Conclusion</h4>The results of the current study revealed no significant relationship between the serum levels of CD73 and the clinicopathological factors in patients with head and neck SCC. Here, NT5E is linked to metastatic malignant neoplasm in the lymph nodes.