However, few studies have assessed the level of this marker in squamous cell carcinoma (SCC) as the most common malignancy of the head and neck region.<h4>Purpose</h4>The aim of this study was to determine the serum levels of CD73 in patients with head and neck SCC to explain their association with clinicopathological parameters.<h4>Materials and method</h4>This cross-sectional study was done on 60 samples taken from patients with head and neck SCC. Here, NT5E is linked to squamous cell carcinoma.