Brain-derived neurotrophic factor (BDNF) regulates energy homeostasis and neuroimmune signaling and may act as a neuroimmunometabolic integrator in PCOS.<h4>Methods</h4>Forty adolescent females with PCOS (26 normal weight and 14 with overweight and obesity) were evaluated. This evidence concerns the gene BDNF and obesity due to melanocortin 4 receptor deficiency.