This study compares infectious burden, wound healing, and immune response among a murine model of spinal implant-associated infection of T2DM, T1DM, and nondiabetic control mice before and after metabolic intervention with the GLP-1 receptor agonist (GLP-1RA), semaglutide.<h4>Methods</h4>Male C57BL/6J mice were rendered diabetic by streptozotocin induction (T1DM) or a high-fat, high-sucrose diet (T2DM). This evidence concerns the gene GLP1R and type 1 diabetes mellitus.