This advanced method allowed us to analyze three sequential transitions (from infertility to biochemical pregnancy, from biochemical pregnancy to clinical pregnancy, and ultimately to live birth) and test for non-linear effects of baseline hormones, including anti-Müllerian hormone (AMH), luteinizing hormone (LH), and antral follicle count (AFC), on the hazard of success at each stage. The gene discussed is PLOD1; the disease is Infertility.