Gene set variation analysis (GSVA) and gene set enrichment analysis (GSEA) were employed to explore the role of nicotinamide phosphoribosyltransferase (NAMPT) in cuproptosis and fibrosis-related pathways.<h4>Results</h4>Transcriptomic analysis identified NAMPT as a key hub gene in IPF, with strong positive correlation to cuproptosis. This evidence concerns the gene NAMPT and idiopathic pulmonary fibrosis.