Differential metabolite abundance and gene expression were evaluated to identify key glycerophospholipid-related genes.<h4>Results</h4>We identified five glycerophospholipid-related genes-AGPAT3, DGAT2, SLC44A1, AGPAT5, and LPGAT1-that were significantly upregulated in NPC and EBER+ tumor-enriched regions. The gene discussed is DGAT2; the disease is nasopharyngeal carcinoma.