By integrating additional CTD curated content for three autism-associated chemicals (bisphenol A, particulate matter, and valproic acid), we discover other mechanisms, including specific genes (e.g., SLC1A1, GSTP1, CNTNAP2) and phenotypes (e.g., lipid metabolism, inflammatory response, social behavior) that can be used to help refine or expand this AOP or create an entirely new pathway for autism. The gene discussed is SLC1A1; the disease is autism.