Notably, [<sup>18</sup>F]KRAS490 also entered the brain, suggesting the potential for central nervous system imaging.<h4>Conclusions</h4>[<sup>18</sup>F]KRAS490 showed specific, blockable tumor uptake and favorable pharmacokinetics, making it a promising tracer for noninvasive imaging of KRAS-G12C mutant tumors. The gene discussed is KRAS; the disease is neoplasm.