To address this limitation, the objective of this study was to engineer biodegradable polymeric microparticles (MPs) loaded with an agonistic CD40 antibody (CMP) to capture HT-released tumor antigens, enabling sustained uptake and presentation by antigen-presenting cells (APCs) while activating dendritic cells (DCs) to enhance APC priming.<h4>Methods</h4>Microparticles were synthesized via a water-in-oil-in-water double emulsion method using PLGA/PCL polymers and an agonistic CD40 antibody. Here, CD40 is linked to neoplasm.