IL10 and Arthritis: MicroRNA profiling revealed enrichment of regulatory miRNAs, including miR-365a-5p, linked to suppression of pro-inflammatory signaling and activation of the IL-10 regulatory axis.<h4>Conclusions</h4>Glycolytic reprogramming enhances the therapeutic potential of UC-MSC-derived EVs, highlighting EVs-UC-MSC<sub>glyco</sub> as promising immunomodulatory candidates for the treatment of autoimmune diseases such as arthritis.