SRC and cancer: Although SRC is one of the earliest identified oncogenic kinases and has been extensively studied as a regulator of cancer progression and migration, it has not yet been successfully translated into an effective therapeutic target in solid tumors, highlighting the need to redefine SRC-targeted strategies in this context.<h4>Methods</h4>Genetic deletion and pharmacological approaches were employed to interrogate SRC function, including comparative evaluation of conventional kinase inhibitors and next-generation inhibitors targeting both kinase and scaffolding functions.