Exosomal <i>miR-27a-3p</i> subsequently targets <i>TGFBR1</i> mRNA in macrophages, thereby suppressing the <i>TGFBR1/smad3</i> signaling pathway and ultimately attenuating MMT and renal fibrosis.<h4>Conclusions</h4><i>BMAL1</i> expression was suppressed in IRI, which promoted MMT and renal fibrosis via the exosomal <i>miR-27a-3p</i>-<i>TGFBR1/smad3</i> pathway. Here, SMAD3 is linked to renal fibrosis.