BMAL1 and renal fibrosis: However, the function of the tubular epithelium-macrophage interaction mediated by <i>BMAL1</i> in IRI-induced renal fibrosis is still unclear.<h4>Methods</h4>A mouse model of kidney-specific <i>BMAL1</i> overexpression was developed to study how <i>BMAL1</i> affects renal fibrosis, exosome production, and the macrophage-to-myofibroblast transition (MMT).