The goal of this study was to test the hypothesis that IGF1R itself regulates cancer cell adhesion.<h4>Methods</h4>We use MDA-MB-231, Hs578T, BT-549 and MCF7 breast cancer cell lines, siRNA-mediated knockdown, and adhesion assays to assess how IGF1R and integrin knockdowns impact cancer cell adhesion. Here, IGF1R is linked to breast cancer.