Patients underwent bariatric surgery (endovascular embolization, gastroplication, or sleeve gastrectomy) with a 12-month follow-up.<h4>Results</h4>With increasing obesity, resistin and leptin levels increase, while adiponectin and ghrelin levels decrease (p < 0.05). The gene discussed is RETN; the disease is obesity due to melanocortin 4 receptor deficiency.