The primary composite endpoint was defined as glycated hemoglobin <6.5%, low-density lipoprotein cholesterol <2.6 mmol/L, systolic blood pressure <130 mmHg, and homeostasis model assessment of insulin resistance <2.5 mmol/L, μU/mL.<h4>Results</h4>At a mean follow-up of approximately 5 years, the mild obesity group achieved lower %TWL than the higher-BMI group (approximately 20% vs 26%, <i>P</i> < 0.05). The gene discussed is INS; the disease is Obesity.