JUN and type 2 diabetes mellitus: In parallel, sciatic nerve analyses showed attenuation of NF-κB/c-Jun-associated inflammatory signaling and modulation of inhibitory regulators at both the protein and mRNA levels.<h4>Conclusion</h4>These findings indicate that MPCI improves T2DM-associated DPN and is associated with splenic immune remodeling and attenuation of peripheral nerve inflammatory signaling, providing exploratory evidence for associations between splenic immune transcriptomic remodeling and peripheral nerve inflammatory signaling.