After adjusting for estimated cell type enrichment, the selectivity of ALDH1A1 attenuation was preserved (adjusted selectivity: -0.210, increased from raw selectivity of -0.190; raw permutation <i>p</i> = 0.0052).<h4>Conclusion</h4>ALDH1A1 co-expression with dopaminergic pathway genes is attenuated in PD substantia nigra across all seven datasets examined. This evidence concerns the gene ALDH1A1 and Parkinson disease.